DNA-Cleaving Anticancer Drugs
derived from Microbial Products

Discovery and total synthesis of calicheamicin

Myotarg (gemtuzumab ozogamicin) - an antileukemia drug
based on calicheamicin (an enediyne antibiotic) - see the
initial sections on structure and mechanism of action

Myotarg (American Pharmaceutical Association page)
See pages 7-8 for mechanism of action.

QuickTime movie of calicheamicin G1

Leinamycin - a representative of a new class of
DNA-cleaving cytotoxins
A large amount of classical organic chemistry
knowledge is necessary for understanding the
mechanism of action of leinamycin - see the linked
article.