Matrix Component
|
Distribution
|
Features
|
Interstitial collagen type 1
|
skin, bone, dentin, tendon, cornea
|
presence of  2 chain, less than 10 hydroxylysines/chain, 0.1% carbohydrate
|
Interstitial collagen type 2
|
cartilage, vitreous body, notochord
|
1% carbohydrate, greater than 10 hydroxylysines/chain
|
Interstitial collagen type 3
|
as type 1, prominent in fetal skin, arteries, amniotic membrane, not in bone or tendon
|
presence of cysteine, high levels of hydroxyproline,glycine, histidine
|
Basement membrane collagen type 4
|
basement membranes (lamina densa)
|
greater than 20 hydroxylysines/chain, high 3-hydroxyproline, low alanine and arginine
|
Collagen type 5
|
associated with membraneous structures
|
slightly larger than 21(1), 0.3% 3-hydroxyproline
|
Fibronectin
|
loose connective tissue matrix, basement membranes, body fluids
|
|
Laminin
|
basement membranes (lamina rara)
|
ordered polypeptide structures (-chain, -sheet, disulfide knot)
|
Tropoelastin-Elastin
|
elastic fibres
|
high content of alanine, valine, glycine contains hydroxyproline, dross-linking
|
Microfibrillin
|
|
|
Proteoglycans
|
|
|
Glycosaminoglycans, sulfated proteoglycans, hyaluronic acid
|
|
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