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| 2/6 | Introduction - the Proteins course | |
| 2/8 | How to read a scientific paper | see link |
| 2/9 | Lab meeting - project prospectus | |
| 2/10 | Research proposal assignment - topic selection | |
| 2/13 | Review of principles of protein structure | LPoB Ch. 5 (pp. 115-129) & 6, 3rd Ed OR Ch. 3 (pp. 75-89) &
Ch. 4, 4th Ed
PSaMP Ch. 1.1-1.7 & 4 & 5 & 6.2 & 6.4 |
| 2/15 | Review of principles of protein function | LPoB Ch. 7 (pp. 203-219) & 8 (243-272) 3rd Ed OR
LPoB Ch. 5 (pp. 157-172) & Ch. 6 (pp. 190-212, Box 6-3) 4th Ed |
| 2/16 | Lab time - culture techniques demo | |
| 2/17 | Protein synthesis - Ribosomes and tRNAs | LPoB Ch. 27 (pp. 1020-1039, 3rd Ed OR pp. 1034-1050 4th Ed)
PSaMP Ch. 2.1 (pp. 49-53) |
| 2/20 | Protein synthesis - Aminoacylation and initiation
RP topics due |
LPoB Ch. 27 (pp. 1039-1043 3rd Ed or pp. 1050-1054 4th Ed)
PSaMP Ch 2.1 (pp. 54) |
| 2/22 | Protein synthesis -Initiation | LPoB Ch. 27 (pp. 1044-1046 3rd Ed OR pp. 1054-1058 4th Ed)
PSaMPCh. 2.1 (pp. 55); supplement |
| 2/23 | Lab time | |
| 2/24 | Protein synthesis - Methods of study | supplement handout |
| 2/27 | Protein synthesis - Methods of study (cont.) | |
| 3/1 | Journal Club 1 - Translation initiation | Eric, Adam C. |
| 3/2 | Lab time | |
| 3/3 | No class | |
| 3/6 | Stop Day | |
| 3/8 | Class and schedule logistics | |
| 3/9 | Lab time | |
| 3/10 | Protein synthesis - Elongation
Bibliography due |
LPoB Ch. 27 (pp1047-1050 3rd Ed OR pp. 1058-1061 4th Ed)
PSaMP Ch. 2.1 (pp. 55-59), supplement |
| 3/13 | SNOW DAY | |
| 3/15 | Protein synthesis - Elongation and termination | LPoB Ch. 27 (pp1047-1052 3rd Ed OR pp. 1058-1062 4th Ed)
PSaMP Ch. 2.1 (pp. 55-59), supplement |
| 3/16 | Lab time | |
| 3/17 | Grant Proposal Writing with Dr. Mike Joyner - Mayo Clinic
Practise Content summary due for Protein Synthesis 1-4 |
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| 3/20 | Protein synthesis - Regulation | supplement on IRE and IRE-BP |
| 3/22 | Journal Club 2- Translational regulation | Adam L., Philip |
| 3/23 | Lab time | |
| 3/24 | Research Proposal - Background Section | |
| 3/25-4/2 |
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| 4/3 | Localization - Secretory proteins | LPoB Ch. 27 (pp. 1056-1061 3rd Ed OR pp. 1068-1071 4th Ed)
PSaMP Ch. 2.3.1; supplement |
| 4/5 | Localization - Mitochondrial proteins | LPoB Ch. 27 (pp. 1061-1063) 3rd Ed ONLY!
PSaMP Ch 2.3.2; supplement |
| 4/6 | Lab time | |
| 4/7 | Localization - Mitochondrial proteins | LPoB Ch. 27 (pp. 1061-1063) 3rd Ed ONLY!
PSaMP Ch 2.3.2; supplement |
| 4/10 | Localization - Nuclear proteins | LPoB Ch. 27 (pp. 1063-1064 3rd Ed OR pp. 1071-1072 4th Ed)
PSaMP Ch. 2.3.3; supplement |
| 4/12 | Journal Club 3 - Mitochondrial protein import | Erik, Andrea |
| 4/13 | Lab Day
Research Proposal-Part I Due |
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| 4/14-4/17 |
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| 4/19 | Research Proposals - Experimental Section | |
| 4/20 | Lab time | |
| 4/21 | Stop Day
Content summary due for Localization or Protein Synthesis |
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| 4/24 | Interactions - Protein-ligand binding | PSaMP Ch. 8.1 |
| 4/26 | Interactions - Protein-ligand binding | PSaMP Ch. 8.2 |
| 4/27 | Lab time - How to make and present a poster
Questions on Research Proposal Experimental |
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| 4/28 | Interactions - Protein-protein | PSaMP Ch. 8.3.1, supplement |
| 5/1 | Interactions - Prions | supplement |
| 5/3 | Antibodies - Structure and ligand binding | LPoB Ch. 7 (pp. 228-231) 3rd Ed OR Che. 5 (pp. 178-180) 4th Ed
PSaMP Ch. 8.3.1 |
| 5/4 | Lab time | |
| 5/5 | Journal Club 4 - Prions in the brain
Research Proposal Final Draft Due |
Krysta, Luis |
| 5/8 | Antibodies - Antigen processing and presentation
Content summary due for Interactions |
LPoB Ch. 7 (pp. 221-228) OR Ch. 5 (pp. 174-178) 4th Ed
see esp. LPoB pp 225-228 3rd Ed; supplemental handout |
| 5/10 | Antibodies - Specificity - polyclonal versus monoclonal | LPoB Ch.7 (pp. 231-233) OR Ch. 5 (pp. 180-182) 4th Ed.
supplemental handout |
| 5/11 | Degradation - Turnover and mechanisms | PSaMP Ch. 10.1-10.3 |
| 5/12 | Poster Previews Day | |
| 5/15 | Degradation - Ubiquitin-mediated
Final posters due for printing! |
LPoB Ch. 27 (pp. 1066 3rd Ed OR pp. 1075-1077 4th Ed)
PSaMPCh. 10.3.3 |
| 5/17 | Ubiquitin-like conjugates
Public Poster Presentations |
supplemental handout |
| 5/23 | Final Exam time Tuesday at 8:00-10:00 a.m.
Content summary due for Antibodies or Degradation |